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Standard nonsurgicaltreatment (oral hygiene instruction, closed subgingival scaling and root plan-ing, and occlusal adjustment where appropriate) should be performed prior tomaking a decision on the type of surgical approach that may be necessary.Often following nonsurgical treatment, a patient who initially presented withgeneralized periodontal inflammation will instead present with most pocketprobing depths at an acceptable level for the maintenance of periodontal health.However, there will frequently be isolated, usually interproximal, defects thatare 5mm or greater in pocket probing depth.

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The six tri-als with ALA supplements or with an ALA-enriched diet were of poorerdesign and smaller size than the fish oil trials, and so their findings wereless impactful. Increased mechanical stressactivates molecular mechanisms similar to those found inthe matrix-producing osteoblasts.

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Gallery: Legends of the Hidden Three Clubs